71989-31-6
- Product Name：Fmoc-L-Proline
- Molecular Formula：C20H19NO4
- Purity：99%
- Molecular Weight：337.375
Product Details;
CAS#： 71989-31-6
Molecular Formula： C20H19NO4
Appearance： white to light yellow crystal powder
Factory Supply High Purity 71989-31-6 Customized Supply
- Molecular Formula:C20H19NO4
- Molecular Weight:337.375
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:7.19E-13mmHg at 25°C
- Melting Point:117-118 °C(lit.)
- Refractive Index:-32.5 ° (C=1, DMF)
- Boiling Point:548.6 °C at 760 mmHg
- PKA:3.95±0.20(Predicted)
- Flash Point:285.6 °C
- PSA：66.84000
- Density:1.328 g/cm3
- LogP:3.42240
Fmoc-L-Proline(Cas 71989-31-6) Usage
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General Description |
The product number for this product was previously 04-12-1031.To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”. |
InChI:InChI=1/C20H19NO4/c22-19(23)18-10-5-11-21(18)20(24)25-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17-18H,5,10-12H2,(H,22,23)/p-1/t18-/m0/s1
71989-31-6 Relevant articles
Versatile Methods to Dispense Submilligram Quantities of Solids Using Chemical-Coated Beads for High-Throughput Experimentation
Martin, M. Cynthia,Goshu, Gashaw M.,Hartnell, Jeffery R.,Morris, Collin D.,Wang, Ying,Tu, Noah P.
, p. 1900 - 1907 (2019)
High-throughput experimentation is a tec...
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Popovici-Muller, Janeta,Lemieux, René M.,Artin, Erin,Saunders, Jeffrey O.,Salituro, Francesco G.,Travins, Jeremy,Cianchetta, Giovanni,Cai, Zhenwei,Zhou, Ding,Cui, Dawei,Chen, Ping,Straley, Kimberly,Tobin, Erica,Wang, Fang,David, Muriel D.,Penard-Lacronique, Virginie,Quivoron, Cyril,Saada, Véronique,De Botton, Stéphane,Gross, Stefan,Dang, Lenny,Yang, Hua,Utley, Luke,Chen, Yue,Kim, Hyeryun,Jin, Shengfang,Gu, Zhiwei,Yao, Gui,Luo, Zhiyong,Lv, Xiaobing,Fang, Cheng,Yan, Liping,Olaharski, Andrew,Silverman, Lee,Biller, Scott,Su, Shin-San M.,Yen, Katharine
supporting information, p. 300 - 305 (2018/04/20)
Somatic point mutations at a key arginin...
Fmoc-OPhth, the reagent of Fmoc protection
Yoshino, Ryo,Tokairin, Yoshinori,Kikuchi, Mari,Konno, Hiroyuki
supporting information, p. 1600 - 1603 (2017/04/03)
Fmoc-OSu has been widely used for Fmoc p...
Polymerization of L-proline functionalized styrene and its catalytic performance as a supported organocatalyst for direct enantioselective aldol reaction
Guo, Guozhang,Wu, Yufeng,Zhao, Xiaowei,Wang, Jing,Zhang, Lei,Cui, Yuanchen
, p. 740 - 746 (2016/08/01)
As an alternative approach to the graft ...
71989-31-6 Process route
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- 28920-43-6
(fluorenylmethoxy)carbonyl chloride
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- 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline
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- 71989-31-6
Fmoc-Pro-OH
| Conditions | Yield |
|---|---|
|
|
95% |
|
With potassium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃;
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95% |
|
With potassium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃;
|
95% |
|
With potassium carbonate; In 1,4-dioxane; water;
|
95% |
|
In ethanol; water; at 60 ℃; for 1h; chemoselective reaction;
|
89% |
|
With potassium carbonate; In 1,4-dioxane; water;
|
89% |
|
With N-ethyl-N,N-diisopropylamine;
|
|
|
In acetonitrile; at 20 ℃; for 0.25h; pH=9.2; aq. borate buffer;
|
-
- 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
-
- 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline
-
- 71989-31-6
Fmoc-Pro-OH
| Conditions | Yield |
|---|---|
|
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; L-proline; With sodium carbonate; In tetrahydrofuran; water; for 48h;
With hydrogenchloride; In tetrahydrofuran; water; pH=2 - 3;
|
91% |
|
With sodium carbonate; In N,N-dimethyl-formamide; for 0.166667h; Ambient temperature;
|
86% |
|
L-proline; With N-cyclohexyl-cyclohexanamine; In acetone; at 20 ℃;
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With sodium carbonate; In water; acetonitrile; at 0 - 20 ℃; pH=8;
With potassium hydrogensulfate; In water; acetonitrile; pH=2 - 3;
|
78% |
|
With sodium carbonate; In tetrahydrofuran; water; for 48h;
|
2.7 g |
|
With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;
|
71989-31-6 Upstream products
-
28920-43-6
(fluorenylmethoxy)carbonyl chloride
-
147-85-3
L-proline
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82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
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88744-04-1
(9-fluorenyl)methyl pentafluorophenyl carbonate
71989-31-6 Downstream products
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71989-32-7
Fmoc-Pro-ONp
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127492-89-1
Ava-Phe-Phe-Pro-Leu-Met-NH2
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125281-19-8
O1,4-(β-D-Glucopyranosyl)-
-
125281-19-8
O1,4-(β-D-Galactopyranosyl)-
Relevant Products
-
Fmoc-L-Ala-OH·H2OCAS：207291-76-7
-
Fmoc-L-aspartic acidCAS：119062-05-4
-
OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTERCAS：843666-40-0
