What is the Fmoc-O-tert-Butyl-L-threonine?

Fmoc-O-tert-Butyl-L-threonine is white to light yellow crystal powder, while it's Molecular Formula is C23H27NO5. white to light yellow crystal powder Used in Peptide Synthesis: Fmoc-O-tert-Butyl-L-threonine is used as a protected amino acid building block for the synthesis of peptides and proteins. The Fmoc group serves as a protecting group for the amino group, while the tert-butyl group protects the hydroxyl group, preventing unwanted side reactions during the assembly process. This allows for the stepwise and controlled formation of peptide bonds in solid-phase peptide synthesis. Used in Organic Synthesis: Fmoc-O-tert-Butyl-L-threonine can also be used as a chiral building block in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and other biologically active compounds. The presence of the L-threonine chiral center and the protecting groups make it a versatile intermediate for the synthesis of enantiomerically pure compounds. Used in Research and Development: Fmoc-O-tert-Butyl-L-threonine is utilized in research and development for the study of peptide synthesis methods, the development of new protecting group strategies, and the investigation of the properties and applications of protected amino acids. It can also be used as a reference compound for analytical methods and quality control in the synthesis of peptides and related compounds.

What is the CAS number for Fmoc-O-tert-Butyl-L-threonine?

The CAS number of Fmoc-O-tert-Butyl-L-threonine is 71989-35-0.

What is Fmoc-O-tert-Butyl-L-threonine (71989-35-0) used for?

Fmoc-O-tert-Butyl-L-threonine, also known as N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-threonine, is a synthetic derivative of the naturally occurring amino acid L-threonine. It is characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group and a tert-butyl (t-Bu) protecting group on the hydroxyl group. Fmoc-O-tert-Butyl-L-threonine is a white to light yellow crystalline powder and is commonly used in the field of organic synthesis and peptide chemistry.InChI:InChI=1/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/p-1/t14-,20+/m1/s1

Product classification

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71989-35-0

Product Name：Fmoc-O-tert-Butyl-L-threonine
Molecular Formula：C₂₃H₂₇NO₅
Purity：99%
Molecular Weight：397.471

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Product Details;

CAS#： 71989-35-0

Molecular Formula： C₂₃H₂₇NO₅

Appearance： white to light yellow crystal powder

Trustworthy Manufacturer Supply Top Purity ≥99.5% 71989-35-0 with Safe Transportation

Molecular Formula:C23H27NO5
Molecular Weight:397.471
Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:2.24E-14mmHg at 25°C
Melting Point:131-134 °C
Refractive Index:15 ° (C=1, AcOEt)
Boiling Point:581.7 °C at 760 mmHg
PKA:3.42±0.10(Predicted)
Flash Point:305.6 °C
PSA：84.86000
Density:1.197 g/cm³
LogP:4.57280

Fmoc-O-tert-Butyl-L-threonine(Cas 71989-35-0) Usage

General Description

The product number for this product was previously 04-12-1000.To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

InChI:InChI=1/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/p-1/t14-,20+/m1/s1

71989-35-0 Relevant articles

A Fmoc - Thr (tBu) - OH preparation method (by machine translation)

-

Paragraph 0031-0038, (2019/02/04)

The invention discloses a Fmoc - Thr (tB...

Unwanted hydrolysis or α/β-peptide bond formation: How long should the rate-limiting coupling step take?

Goldschmidt G?z, Viktória,Nagy, Adrienn,Farkas, Viktor,Keszei, Ern?,Perczel, András

, p. 30720 - 30728 (2019/10/28)

Nowadays, in Solid Phase Peptide Synthes...

A one-pot procedure for the preparation of N-9-fluorenylmethyloxycarbonyl- α-amino diazoketones from α-amino acids

Siciliano, Carlo,De Marco, Rosaria,Guidi, Ludovica Evelin,Spinella, Mariagiovanna,Liguori, Angelo

, p. 10575 - 10582 (2013/02/22)

The study describes a new "one-pot" rout...

Derivates of Polyethylene Glycol Modified Thymosin Alpha 1

-

, (2010/08/07)

Pharmaceutical compositions that include...

71989-35-0 Process route

: 67-56-1
methanol

: 72-19-5,134357-96-3,7013-32-3,82822-12-6
L-threonine

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 115-11-7,15220-85-6
isobutene

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

Conditions

Conditions	Yield
methanol; L-threonine; With thionyl chloride; at 40 - 45 ℃; for 20h; isobutene; With sulfuric acid; In dichloromethane; at 0 - 5 ℃; N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; Further stages;

: (2S,3R)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid 2-trimethylsilanyl-ethoxymethyl ester

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH