109745-15-5

  • Product Name:FMOC-D-GLU-OTBU
  • Molecular Formula:C24H27 N O6
  • Purity:99%
  • Molecular Weight:425.481
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Product Details;

CAS#: 109745-15-5

Molecular Formula: C24H27 N O6

Appearance: White Powder

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  • Molecular Formula:C24H27 N O6
  • Molecular Weight:425.481
  • Appearance/Colour:White Powder 
  • Vapor Pressure:3.72E-17mmHg at 25°C 
  • Boiling Point:638.1oC at 760 mmHg 
  • PKA:4.46±0.10(Predicted) 
  • Flash Point:339.7oC 
  • PSA:101.93000 
  • Density:1.232g/cm3 
  • LogP:4.49110 

FMOC-D-GLU-OTBU(Cas 109745-15-5) Usage

General Description

FMOC-D-GLU-OTBU is a chemical compound that consists of FMOC (fluorenylmethyloxycarbonyl) protecting group, D (dextro) configuration of the glutamic acid, and OTBU (tert-butyl ester) protecting group. The FMOC protecting group is commonly used in peptide synthesis to protect the amino group of an amino acid and allows for stepwise assembly of peptides. The D configuration of the glutamic acid indicates that the molecule is a mirror image of the L configuration typically found in biological systems. The OTBU protecting group is used to protect the carboxylic acid group of the glutamic acid. Overall, FMOC-D-GLU-OTBU is a compound that is commonly used in peptide synthesis and organic chemistry research.

InChI:InChI=1/C24H27NO6/c1-24(2,3)31-22(28)20(12-13-21(26)27)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,27)/t20-/m1/s1

109745-15-5 Relevant articles

Synthesis of cell-wall analogues of vancomycin-resistant Enterococci using solid phase peptide synthesis

Cho, Younghoon R.,Entress, Richard M. H.,Williams, Dudley H.

, p. 5229 - 5232 (1997)

A convenient method for the direct coupl...

109745-15-5 Process route

(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-tert-butyl ester

(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-allyl ester 1-tert-butyl ester

(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid
109745-15-5

(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid

Conditions
Conditions Yield
With tetrakis(triphenylphosphine) palladium(0); benzotriazol-1-ol; Yield given;
 
D-Glutamic acid
6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6

D-Glutamic acid

(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid
109745-15-5

(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
3: tetrakis(triphenylphosphine) palladium(0), HOBt
With tetrakis(triphenylphosphine) palladium(0); benzotriazol-1-ol;
 

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