
35661-60-0
- Product Name:Fmoc-L-Leucine
- Molecular Formula:C21H23NO4
- Purity:99%
- Molecular Weight:353.418
Product Details;
CAS#: 35661-60-0
Molecular Formula: C21H23NO4
Appearance: white to light yellow crystal powder
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- Molecular Formula:C21H23NO4
- Molecular Weight:353.418
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:2.28E-13mmHg at 25°C
- Melting Point:152-156 °C(lit.)
- Refractive Index:-25 ° (C=1, DMF)
- Boiling Point:559.8 °C at 760 mmHg
- PKA:3.91±0.21(Predicted)
- Flash Point:292.4 °C
- PSA:75.63000
- Density:1.207 g/cm3
- LogP:4.41530
Fmoc-L-Leucine(Cas 35661-60-0) Usage
Biological Activity |
Anti-inflammatory agent; increases intracellular Ca 2+ levels. |
Biochem/physiol Actions |
PPARγ ligand that induces insulin sensitization, but not adipogenesis. |
InChI:InChI=1/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/p-1/t19-/m1/s1
35661-60-0 Relevant articles
Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones
Einsiedler, Manuel,Jamieson, Cooper S.,Maskeri, Mark A.,Houk, Kendall N.,Gulder, Tobias A. M.
supporting information, p. 8297 - 8302 (2021/03/01)
Previous studies showed that the FeII/α-...
Kras inhibitory cyclic peptide compound
-
Paragraph 0682; 0821; 0824, (2021/06/03)
The following were discovered: a cyclic ...
Novel chiral stationary phases based on 3,5-dimethyl phenylcarbamoylated β-cyclodextrin combining cinchona alkaloid moiety
Zhu, Lunan,Zhu, Junchen,Sun, Xiaotong,Wu, Yaling,Wang, Huiying,Cheng, Lingping,Shen, Jiawei,Ke, Yanxiong
, p. 1080 - 1090 (2020/05/25)
Novel chiral selectors based on 3,5-dime...
Unwanted hydrolysis or α/β-peptide bond formation: How long should the rate-limiting coupling step take?
Goldschmidt G?z, Viktória,Nagy, Adrienn,Farkas, Viktor,Keszei, Ern?,Perczel, András
, p. 30720 - 30728 (2019/10/28)
Nowadays, in Solid Phase Peptide Synthes...
35661-60-0 Process route
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- 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

-
- 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

-
- 35661-60-0
Fmoc-Leu-OH

-
- 35737-10-1
N-Fmoc-β-alanine

-
- 24324-17-2
9-Fluorenylmethanol
Conditions | Yield |
---|---|
With water; potassium carbonate; In acetonitrile; at 20 ℃; for 6h;
|
70 %Chromat. 10 %Chromat. 22 %Chromat. |
-
- 28920-43-6
(fluorenylmethoxy)carbonyl chloride

-
- 170642-24-7
(R)-2-Amino-4-methyl-pentanoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

-
- 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

-
- 35661-60-0,126727-03-5,114360-54-2
N-(9-fluorenylmethoxycarbonyl)-D-leucine
Conditions | Yield |
---|---|
With sodium hydroxide; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) reflux, 2.) 1.5 h;
|
35661-60-0 Upstream products
-
61-90-5
L-leucine
-
28920-43-6
(fluorenylmethoxy)carbonyl chloride
-
102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate
-
88744-04-1
(9-fluorenyl)methyl pentafluorophenyl carbonate
35661-60-0 Downstream products
-
71989-25-8
Fmoc-Leu-ONp
-
113534-30-8
Fmoc-Leu-OTDO
-
17195-26-5
Leu-Ala-Gly-Val
-
139932-46-0
phenyl 3-<(4'-Nα-9-fluorenylmethoxycarbonylleucyloxymethyl)-phenyl>-3-trimethylsilylpropanoylglycinate
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